Research Projects

Acetylcholine is a neuromodulator which plays a crucial role in learning, memory and attention. We are studying how acetylcholine influences brain dynamics and how disruptions in this neuromodulatory system contribute to various neurological conditions. We are investigating the relationship between acetylcholine signaling, neuronal activity and cognitive behaviors. Our study focusing on acetylcholine and neuromodulation of neural circuits will deepen our understanding of the physiological role of acetylcholine in the brain and help us identify potential therapeutic targets for neurological disorders. 

Dysfunctions in cholinergic signalling are associated with major psychiatric disorders, including schizophrenia, which is a severe mental illness affecting 1 in 300 people worldwide. Despite recent advancements in treatment, schizophrenia remains mysterious and imposes a significant societal burden. Impairment of cognitive processes that are heavily dependent on the prefrontal cortex is a characteristic feature of schizophrenia, and it is linked to reduced activity in the default mode network. Neurons in the prefrontal cortex express acetylcholine receptors and receive substantial input from cholinergic signals, influencing cognitive behaviours by regulating the activity of neuronal networks. Major genome-wide association studies identified human polymorphisms of cholinergic genes that predispose to schizophrenia and nicotine addiction, however their role on the circuit mechanisms underlying schizophrenia is unknown.

Experimental data indicate a correlation between dysfunctions of the cholinergic neuromodulatory system and the development of Alzheimer’s disease. However, despite treatments aimed at enhancing acetylcholine levels in the brain, long-term improvements remain elusive. Consequently, the precise role of cholinergic dysfunctions in contributing to Alzheimer’s disease pathology remains a subject of controversy. Using state of the art techniques, we aim to understand the role of acetylcholine receptors in the neuronal mechanisms behind the  cortical hyperactivity that is observed in Alzheimer's disease. Our ultimate goal is to provide novel targets for drug development.